The Department of Pathology and Cell Biology at Columbia University Irving Medical Center seeks a highly qualified Senior Staff Associate to develop, validate and run High Resolution Mass Spectrometry-based quantitative drug and exposomics assays in support of patient care. The ARPA-H funded project is part of a multi-institutional effort (IndiPHARM) led by Dr Gary Miller from Columbia University, School of Public Health. The project itself is led by Drs Serge Cremers, and Alex Lyashchenko who will be overseeing the activities of the research scientist in the Clinical Pharmacology and Toxicology Laboratory of the Department of Pathology and Cell Biology at Columbia University Irving Medical Center.
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Lab Mission/Purpose:
The Clinical Pharmacology and Toxicology Laboratory of the Department of Pathology and Cell Biology is a state-of-the-art CLIA-, CAP, and New York State Department of Health?accredited academic clinical laboratory that develops and offers LC-MS? and HPLC-based assays for drugs in support of patient care. The laboratory?s rapidly expanding test menu includes routine assays for drugs that are also offered by other clinical laboratories but its primary focus is on drugs for which therapeutic drug monitoring is not available anywhere else. In addition, the laboratory?s unique position within one of the world?s leading medical centers enables early translation of assays for drugs in development into patient care. Assays are developed and offered for patient care in close collaboration with academic research groups as well as pharmaceutical and diagnostic companies.
In addition to reporting drug levels, the laboratory provides consults with respect to the interpretation of drug levels using pharmacokinetic software and integrating chemistry, clinical, and genetic data into the therapeutic drug monitoring process.
Job Function :
Develop and validate High Resolution Liquid Chromatography Mass Spectrometry ? based panel assays to quantify drugs, metabolites and exposomics markers in serum and plasma of patients in support of their care. The panel assays are to be approved by NY State Department of Health.
The panels are focused on drugs and exposomics markers relevant for the treatment of diabetes and obesity and psychiatric diseases.
The assays will be developed on an Thermo-Scientific Exploris-120 Orbitrap instrument.
After development and successful validation of the panel assays they are to be run in support of patient care.
The development of the assays will take place in close collaboration with the other investigators involved in the IndiPHARM project, especially Dr Gary Miller?s group from Columbia?s School of Public Health and Dr Douglas Walker from Emory University.
The ideal candidate is licensed in the state of NY as a medical technologist, or they will be eligible to apply for (restricted toxicology) licensure.
Minimum Education Requirements:
Bachelor's Degree in pharmacology, toxicology, bioanalytical chemistry, pharmaceutical sciences, or a related area. Master?s degree or equivalent combination of education and experience preffered.
Minimum Skills Required:
Experience developing and validating assays with LCMS, preferably with an Orbitrap.
Preferred Qualifications :
PhD
Hiring Salary Range:
Columbia University is an Equal Opportunity Employer / Disability / Veteran
Pay Transparency Disclosure
The salary of the finalist selected for this role will be set based on a variety of factors, including but not limited to departmental budgets, qualifications, experience, education, licenses, specialty, and training. The above hiring range represents the University?s good faith and reasonable estimate of the range of possible compensation at the time of posting.
About Columbia University
Columbia University is one of the world's most important centers of research and at the same time a distinctive and distinguished learning environment for undergraduates and graduate students in many scholarly and professional fields. The University recognizes the importance of its location in New York City and seeks to link its research and teaching to the vast resources of a great metropolis. It seeks to attract a diverse and international faculty and student body, to support research and teaching on global issues, and to create academic relationships with many countries and regions. It expects all areas of the university to advance knowledge and learning at the highest level and to convey the products of its efforts to the world.
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